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Past Grants
9/15/2004 - 9/14/2005
Maria D. Ledesma, Ph.D. (Fundazione Cavalieri Ottolenghi; Turin, Italy)
Organization of Synapses in Niemann-Pick Disease Type A
$50,000
4/1/2004 - 3/31/2005
Synthia Mellon, Ph.D. (University of California, San Franciso; San Francisco, California, USA)
SSRIs as a potential therapy for NP-C
$97,769 (Jointly funded with Dana's Angels Research Trust)
3/1/2004 - 2/28/2005
Stuart A. Lipton, M.D., Ph.D. (The Burnham Institute; La Jolla, California, USA)
NMDA receptor hypofunction in Niemann-Pick disease Type A
$50,000
9/15/2003 - 9/14/2004
Makoto Michikawa, M.D., Ph.D. (National Institute for Longevity Sciences; Aichi, Japan)
Cellular and Molecular Mechanisms Underlying Neurodegeneration in Niemann- Pick Type C disease
$50,000
7/1/2003 - 8/31/2004
Timothy M. Cox, MD (University of Cambridge; Cambridge, United Kingdom)
Therapeutic Gene Delivery to the Cerebellum in Niemann-Pick Type C
$40,000 (Transitional Funding - used for PostDoc)
8/15/2002 - 8/14/2003
Maria D. Ledesma, Ph.D. (Fundazione Cavalieri Ottolenghi; Turin, Italy)
Niemann-Pick Disease Type A: Molecular Analysis of Neuronal Membrane Maturation and Synapse Formation
$50,000
8/1/2002 - 7/31/2003
Anita H. Corbett, Ph.D. (Emory University School of Medicine; Atlanta, Georgia, USA)
Functional Analysis of NPC1
$50,000
2/15/2002 - 2/14/2003
Melanie Jean Dobson, Ph.D. (Dalhousie University; Halifax, Nova Scotia, Canada)
A Yeast System for Analysis of Sterol Trafficking Defects in NPC
$42,000
8/15/2001 - 8/14/2003
Daniel S. Ory, M.D. (Washington University School of Medicine; St. Louis, Missouri, USA)
The Role of HE1 in Cholesterol Trafficking
$154,147
8/15/2001 - 8/14/2002
Skadrite Krisans, Ph.D. (San Diego State University; San Diego, California, USA)
Role of Peroxisomal Cholesterol/Myelin Formation in the CNS Pathology of the NPC Mouse
$50,000
2/1/2001 - 1/31/2002
Anthony H. Futerman, Ph.D. (Weizmann Institute; Rehovot, Israel)
Neuronal Development & Death in Type A Niemann-Pick Disease
$50,000
8/15/2000 - 8/14/2001
Mary Anna Thrall, DVM (Colorado State University; Fort Collins, Colorado, USA)
Characterization of Feline Niemann-Pick Type C
$40,216
9/1/2000 - 8/31/2001
Yiannis A. Ioannou, Ph.D. (Mount Sinai School of Medicine; New York, New York, USA)
Functional Characterization of NPC1L1, a Human Homologue of NPC1
$60,000
8/15/2000 - 8/14/2003
Robert A. Maue, Ph.D. (Dartmouth College)
Analysis of Growth Factor Actions and Membrane Polarity in Neurons from NP-C Mice
$131,988
4/22/2000
Daniel S. Ory, M.D. (Washington University School of Medicine; St. Louis, Missouri, USA)
Molecular Cloning of the Niemann-Pick Type C2 Gene
$125,752
2/21/2000
Cynthia J. Forehand, Ph.D. (University of Vermont; Burlington, Vermont, USA)
Glutamate Receptors and Neuronal Degeneration in Niemann-Pick Type C Disease
$27,107
4/20/2000
Lisa D. Griffin, M.D., Ph.D. (University of California - San Francisco; San Francisco, California, USA)
Altered Neurosteroidogenesis in Niemann-Pick Type C Disease
$40,000
2/19/2000
James Shayman, M.D. (University of Michigan; Ann Arbor, Michigan, USA)
Treatment of Niemann-Pick Type C Disease with Potent Inhibitors of Cerebroside Synthase
$40,000
8/18/1999
Leslie P. Henderson (Dartmouth College, Hanover, New Hampshire, USA)
Analysis of NPC1 mRNA Expression in the Mouse Brain
$14,592
7/17/1999
Daniel Ory, M.D. (Washington University School of Medicine; St. Louis, Missouri, USA)
Molecular Cloning of NPC2 Gene
$110,000
6/16/1999
Lisa Griffin, M.D., Ph.D. (University of California - San Francisco; San Francisco, California, USA)
The Role of Neurosteroids in the Development of Niemann-Pick Type C
$34,000
6/15/1999
Frederick R. Maxfield, Ph.D.(Weill Medical College of Cornell University; New York, New York, USA)
Intracellular Cholesterol Trafficking in Niemann-Pick Type C Disease
$15,000
9/14/1998
Jerry Reagan, Ph.D. (Wake Forest University School of Medicine; Winston-Salem, North Carolina, USA)
Acid Sphingomyelinase Regulates Cholesterol Egress from Lysosomes by an Alternative Pathway
$15,000
4/13/1998
Daniel Ory, M.D. (Washington University School of Medicine; St. Louis, Missouri, USA)
Molecular Cloning of NPC2 Gene
$60,000
2/12/1998
Jill Morris, Ph.D. (National Institutes of Health; Bethesda, Maryland, USA)
Identification of Additional NPC1 Mutations
$31,000
3/11/1998
Ira Tabas, M.D., Ph.D. (Columbia University; New York, New York, USA)
Phospholipid Metabolism and Cholesterol-Induced Cytotoxicity in Niemann-Pick C Macrophages
$15,000
3/10/1998
Leslie P. Henderson, Ph.D. (Dartmouth College, Hanover, New Hampshire, USA)
Analysis of NPC1 mRNA Expression in the Mouse Brain
$14,742
3/9/1997
Marc Patterson, M.D. (Mayo Clinic; Rochester, Minnesota, USA)
Lipid Trafficking in the Neurons of NPC Mice
$11,000
1/8/1997
Synthia Mellon, Ph.D. (University of California - San Francisco; San Francisco, California; USA)
Potential Involvement of Neurosteroids in the Neurobiological Dysfunctions of NP-C
$30,044
10/7/1996
Marc Patterson, M.D. (Mayo Clinic; Rochester, Minnesota, USA)
Establish an International Registry (database) of NPC Families
$10,213
7/6/1996
G. S. Tint, Ph.D. (Veterans Adminstration Medical Center; East Orange, New Jersey, USA)
Accumulation of Oxidized Cholesterol as a Possible Cause of Pathologies Associated with Niemann-Pick Type C Disease
$14,000
6/5/1996
John R. Sargent, Ph.D. (University of Stirling; Stirling, Scotland, United Kingdom)
Influence of Exogenous Fatty Acids on Levels of Cholesterol in Cultured Skin Fibroblasts from NPC Patients
$28,050
1/4/1996
Wenda L. Greer, Ph.D. (Dalhousie University; Halifax, Nova Scotia, Canada)
Identification of Niemann-Pick Type D Patients with Arcadian Ancetsry as a Step Toward Isolation of the Defective Gene
$12,357
11/3/1995
Charles C. Schwartz, M.D. (Medical College of Virginia; Richmond, Virginia, USA)
Quantitation of Cholesterol Transport and Tissue Cholesterol Pool Sizes In Vivo Niemann-Pick Type C Disease
$32,000
4/2/1994
Laura Liscum, Ph.D. (Tufts University School of Medicine; Boston, Massachusetts, USA)
Complementation Analyses of Niemann-Pick Type C Fibroblasts' Cholesterol Transport in Defective CHO Cells
$8,900
7/1/1993
Eugene Carstea, Ph.D. (National Institutes of Health; Bethesda, Maryland, USA)
Identify the Gene Responsible for Niemann-Pick Type C Disease
$160,000
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