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Current and Recent

Research Grants

 

3/1/2007 - 3/1/2008.

Frances M. Platt (Dept. of Pharmacology, University of Oxford).  Evaluation of anti-inflammatory intervention (NSAIDS) as an adjunctive therapy in Niemann-Pick Type C1 disease.  Click here to read a summary of this project.

4/1/2007

Lysosomal Storage Disease Research Consortium. 

Continuation of support for research into issues common to all lysomsome storage diseases.

9/1/2006 - 8/31/2007

Maria D. Ledesma, Ph.D. (Catholic University of Leuven; Leuven; Belgium)

Informational Analysis of Dendritic Spine Alterations in Niemann-Pick Disease Type A Neurons

6/1/2006 - 12/31/2007

Kostantin Dobrenis, Ph.D. (Albert Einstein College of Medicine of Yeshiva University; Bronx, New York; USA)

Establishment of Central Nervous System Cell Lines from NPC-1 Disease Mice for Pathogenic and Therapeutic Studies

4/1/2006 

Lysosomal Storage Disease Research Consortium

NNPDF provides annual support to the LSD Research Consortium for research into issues common to all lysososome storage diseases.

9/15/2004 - 9/14/2007

Nobutaka Ohgami, Ph.D. Sponsor: T. Y. Chang, Ph.D. (Dartmouth Medical School; Hanover, New Hampshire; USA)

Demonstration of NPC1 as a lipid binding protein in Vitro.

5/1/2006 - 11/30/2006

Frances M. Platt, Ph.D. (University of Oxford; Oxford, England; UK)

Therapeutic Monitoring of Glycolipid Storage Diseases in the Clinic Using Cell Biological Assays and Proteomics

4/15/2005 - 4/14/2006

Robert A. Maue, Ph.D. (Dartmouth Medical School; Hanover, New Hampshire; USA)

Maintenance of Colony of NPC1 mice with GFP-tagged Purkinje neurons

5/1/2005 - 4/30/2006

Thomas J. Kelley, Ph.D. (Case Western Reserve University; Cleveland, Ohio; USA)

NOS2 regulation in NPC

(Major funding provided by The Niemann-Pick Disease Group UK)

4/1/2005 - 4/1/2007

Richard E. Pagano, Ph.D. and David L. Marks, Ph.D. (Mayo Clinic and Foundation; Rochester, Minnesota; USA)

Reduction of stored lipids in Niemann-Pick Type C mice by rab protein expression